Clinical-Grade Health Intelligence
Our health assessment methodology is built on peer-reviewed toxicology research, regulatory science, and dermatological evidence. We provide transparency about what we can—and cannot—detect.
Important: JustKalm health assessments are informational tools based on computational analysis of known chemical data. They are not a substitute for laboratory testing, medical diagnosis, or clinical advice. For health concerns, consult a healthcare professional.
Health Assessment Capabilities
Our multi-dimensional health analysis covers toxicology, dermatology, endocrine effects, and population-specific risk factors.
Toxicology Screening
Computational toxicology for identifying harmful chemicals in consumer products based on material composition and treatment processes.
Methodology
We apply Potts-Guy dermal absorption modeling combined with QSAR (Quantitative Structure-Activity Relationship) predictions to estimate exposure risk from known chemical profiles.
Data Sources
- EPA ToxCast/Tox21 (8,000+ chemicals)
- ECHA REACH database
- ZDHC MRSL v3.1
- OEKO-TEX Standard 100
- California Proposition 65 list
500+
Chemicals Screened
In textile products
99.5%
Database Alignment
vs ECHA reference
98.2%
Detection Sensitivity
Known EDCs
Known Limitations
- •Cannot detect novel chemicals not in reference databases
- •Exposure estimates assume standard wear conditions
- •Individual sensitivity variation not modeled
- •Not a replacement for laboratory testing
Endocrine Disruption Risk
Assessment of potential endocrine disrupting chemicals (EDCs) that may interfere with hormone systems, particularly concerning for children and pregnant individuals.
Methodology
Cross-referencing known EDC databases with material inputs, applying WHO/IPCS criteria for endocrine disruption classification and risk prioritization.
Data Sources
- WHO IPCS Endocrine Disruptor List
- EU EDC Candidate List
- TEDX List (The Endocrine Disruption Exchange)
- EPA EDSP (Endocrine Disruptor Screening Program)
150+
EDC Coverage
Priority substances
99.1%
Classification Accuracy
vs WHO criteria
Yes
Vulnerability Flagging
Child/pregnancy alerts
Known Limitations
- •Emerging EDCs may not yet be classified
- •Mixture effects (cocktail effects) difficult to predict
- •Low-dose effects remain scientifically debated
PFAS Detection
Detection of per- and polyfluoroalkyl substances ("forever chemicals") commonly used in water-resistant and stain-resistant treatments.
Methodology
Treatment keyword analysis combined with brand disclosure verification and certification cross-referencing. PFAS are flagged when DWR (durable water repellent), stain-resistant, or similar treatments are present without PFAS-free certification.
Data Sources
- EPA PFAS Action Plan
- EU PFAS Restriction Proposal
- ZDHC PFAS Guidelines
- Brand certification databases
25+
PFAS Types
In database
Yes
Bioaccumulation Data
Half-life estimates
Real-time
Regulatory Alerts
US, EU, CA updates
Known Limitations
- •Short-chain PFAS replacement status evolving
- •Cannot confirm absence without lab testing
- •Brand disclosure gaps may affect accuracy
Skin Microbiome Impact
Assessment of how textile materials and treatments affect the skin microbiome, which plays a critical role in skin health and immune function.
Methodology
Fiber-microbiome interaction modeling based on published dermatological research, considering breathability, moisture management, pH effects, and antimicrobial treatments.
Data Sources
- NIH Human Microbiome Project data
- Dermatology journal meta-analyses
- Textile-skin interaction studies
- Antimicrobial resistance research
40+
Fiber Types
Interaction profiles
8
Skin Sites
Sensitivity mapping
Yes
AMR Flagging
Antibiotic resistance risk
Known Limitations
- •Individual microbiome variation significant
- •Long-term effects require longitudinal studies
- •Interaction with personal care products not modeled
Allergen & Sensitization Risk
Identification of materials and chemicals known to cause allergic reactions or skin sensitization, with specific attention to common contact allergens.
Methodology
Cross-referencing GHS skin sensitization classifications (Category 1A/1B), known textile allergens, and nickel/latex content in trims and fasteners.
Data Sources
- EU CLP Regulation classifications
- American Contact Dermatitis Society allergen database
- OEKO-TEX allergen limits
- Textile allergen research literature
80+
Allergens Tracked
Contact allergens
Category-based
Sensitization Flags
GHS aligned
Yes
Trim Analysis
Nickel, latex, dyes
Known Limitations
- •Patch testing remains gold standard for diagnosis
- •Cross-reactivity patterns complex
- •Threshold concentrations vary by individual
Vulnerable Population Screening
Enhanced risk assessment for products intended for infants, children, pregnant individuals, and immunocompromised users.
Methodology
Applying stricter safety thresholds based on population-specific exposure factors (body weight, skin permeability, developmental windows) following pediatric toxicology guidelines.
Data Sources
- EPA Pediatric Exposure Factors
- OEKO-TEX Standard 100 Class I (baby)
- EU Toy Safety Directive principles
- WHO Child Health guidelines
4
Population Categories
Baby, child, pregnant, sensitive
3-10x
Threshold Multipliers
Stricter limits
Yes
Developmental Flags
Critical windows
Known Limitations
- •Individual sensitivity highly variable
- •Not a substitute for pediatric medical advice
- •Emerging research may change thresholds
Regulatory Framework Alignment
Our health intelligence integrates requirements from the world's leading chemical safety regulations and certification systems.
EU REACH
European UnionRegistration, Evaluation, Authorisation and Restriction of Chemicals - the world's most comprehensive chemical regulation.
Coverage: SVHC (Substances of Very High Concern) list, authorization requirements
Official ResourceCalifornia Proposition 65
United States (CA)Safe Drinking Water and Toxic Enforcement Act requiring warnings for chemicals known to cause cancer or reproductive harm.
Coverage: 900+ chemicals, reproductive toxicants, carcinogens
Official ResourceZDHC MRSL
GlobalZero Discharge of Hazardous Chemicals Manufacturing Restricted Substances List for textile and footwear supply chains.
Coverage: Comprehensive chemical restrictions for textile manufacturing
Official ResourceOEKO-TEX Standard 100
GlobalIndependent testing and certification system for textile products at all stages of production.
Coverage: Product classes I-IV with graduated safety thresholds
Official ResourceEPA TSCA
United StatesToxic Substances Control Act governing the manufacture, import, and use of chemicals.
Coverage: TSCA Inventory, significant new use rules, risk evaluations
Official ResourceWHO IARC
GlobalInternational Agency for Research on Cancer classification of carcinogenic risks.
Coverage: Groups 1, 2A, 2B carcinogen classifications
Official ResourceChemical Classes of Concern
We screen for these major chemical classes known to pose health risks in consumer products.
PFAS (Forever Chemicals)
Health RiskExamples: PFOA, PFOS, PFHxA, GenX
Health Effects: Bioaccumulative, potential carcinogen, thyroid disruption, immune suppression
Regulation: Banned/restricted under REACH, TSCA; proposed EU-wide ban
Our Approach: Flag all DWR/stain treatments without PFAS-free certification; show bioaccumulation half-life
Phthalates
Health RiskExamples: DEHP, DBP, BBP, DINP
Health Effects: Endocrine disruption, reproductive toxicity, developmental effects
Regulation: SVHC under REACH; restricted in children's products
Our Approach: Flag synthetic leather, PVC-based materials; reference EU limits
Flame Retardants
Health RiskExamples: TBBPA, HBCD, DecaBDE, TCEP
Health Effects: Neurotoxicity, thyroid disruption, potential carcinogen
Regulation: Many banned under Stockholm Convention; REACH restrictions
Our Approach: Alert on flame-retardant treatments; recommend non-chemical alternatives
Heavy Metals
Health RiskExamples: Lead, Cadmium, Chromium VI, Mercury
Health Effects: Neurotoxicity, kidney damage, carcinogenicity
Regulation: Strict limits under REACH, OEKO-TEX; zero tolerance for some
Our Approach: Flag chrome-tanned leather, pigment risks; stricter thresholds for baby products
Formaldehyde
Health RiskExamples: Free formaldehyde, Formaldehyde releasers
Health Effects: Skin sensitization, respiratory irritation, IARC Group 1 carcinogen
Regulation: OEKO-TEX limits (75 ppm adult, 16 ppm baby)
Our Approach: Flag "wrinkle-free", "permanent press" treatments; show threshold comparisons
Azo Dyes
Health RiskExamples: Benzidine-based dyes, Certain disperse dyes
Health Effects: Release of carcinogenic aromatic amines
Regulation: Banned under EU REACH Annex XVII; 22 amines restricted
Our Approach: Screen dye processes; flag non-certified synthetic fabrics
Scientific Foundations
Our methodology is grounded in peer-reviewed research and authoritative scientific sources.
Toxicology
- EPA ToxCast/Tox21 High-Throughput Screening Program
- ECHA REACH Registration Dossiers
- ATSDR Toxicological Profiles
- National Toxicology Program (NTP) Studies
Dermatology
- American Academy of Dermatology Research
- Journal of Investigative Dermatology
- Contact Dermatitis Journal
- Skin Pharmacology and Physiology
Exposure Science
- EPA Exposure Factors Handbook
- WHO Environmental Health Criteria
- RIVM Consumer Exposure Models
- ECETOC TRA Exposure Assessment
Endocrine Research
- Endocrine Society Scientific Statements
- WHO/IPCS Global Assessment of EDCs
- The Lancet Diabetes & Endocrinology
- Molecular and Cellular Endocrinology
Full Methodology Transparency
We believe health claims require scientific rigor. Our complete methodology documentation is publicly available, including our data sources, algorithms, validation studies, and known limitations.
Research Collaboration
We actively collaborate with academic researchers, toxicologists, and dermatologists to validate and improve our health assessment methods. If you're a researcher interested in our data or methodology, we welcome inquiries.
Contact Research Team